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Karyopharm Therapeutics is driven by the extraordinary strength and courage of the patients we serve. What began as a visionary, founder-led start-up has evolved into a global leader in oncology innovation committed to transforming cancer treatment with bold, cutting-edge therapies. Our pioneering SINE (Selective Inhibition of Nuclear Export) technology targets cancer cells in a revolutionary way, offering hope for patients with both blood cancers and solid tumors.
Headquartered in Newton, Massachusetts, we’ve expanded our global presence with our first FDA approved product now available across the U.S., Europe and Asia. Building on our success in multiple myeloma, Karyopharm is advancing a promising clinical pipeline that extends beyond oncology, with innovative compounds also targeting rare diseases.
As we continue leading in oncology innovation, we are not just about advancing science; we are inspired daily by the patients we serve and fueled by the energy and resilience required to face challenges head-on. From our beginnings rooted in remarkable science to our position as a commercial-stage leader, Karyopharm is shaping a future that aims to redefine cancer care and improve lives.
Newton, MA
Karyopharm is charting a bold path forward, cultivating innovation to achieve their mission of defeating cancer. Through relentless determination and a patient-centric focus, every employee throughout the organization plays a pivotal role in delivering life-changing therapies. By advancing an already strong pipeline, embracing new opportunities, and pushing the boundaries of what’s possible, they’re not just imagining a better future for patients—they are building it.
Karyopharm employees are committed to operating by a set of values that help them challenge the status quo in pursuit of excellence. Their values, known as ICARE - Innovation, Courage, Alignment, Resilience, and Energy - shape a unified culture where they turn challenges into opportunities that will help them achieve their shared purpose of defeating cancer. These values also form the foundation their talent management, personal development, and rewards and recognition systems, which include celebrating achievement through ICARE Awards that recognize everyday acts of collaborations and accountability.
Richard Paulson, Karyopharm’s CEO, champions a culture of innovation and resiliency by driving bold decisions and focusing on employee engagement. Under Richard’s leadership, the company has successfully navigated inherent challenges of scaling a commercial-stage biotech organization, while maintaining an unwavering commitment to the development of new novel therapies to help patients. He is a visionary leader who sets clear goals, and genuinely cares about people. Richard empowers teams to deliver, aligns the organization, and unites employees in our shared mission to transform cancer care.
At Karyopharm, respect is at the foundation of how employees work together. They create and foster an environment where employees feel heard through open forums and programs that promote transparency, integrity, respect, and diversity of thought. Their performance reviews and development processes embrace the whole person, recognizing and valuing the differences and uniqueness of each employee. In addition, Karyopharm is committed to the Inclusion & Wellness of all employees – supporting employee resource groups to celebrate multicultural teams to ensure that respect and inclusion fuel our collective success.
Karyopharm thrives on a profound sense of shared purpose. Our dynamic, cross-functional environment breaks down silos, fostering connections between teams and empowering them to innovate and adapt with agility. Every contribution is not only valued but actively encouraged, creating a culture where employees are equipped and inspired to take on complex challenges and deliver transformative solutions. The company size allows it to easily unite diverse perspectives and harness collective expertise, amplifying employees’ impact and accelerating progress toward achieving their mission.
New hires to Karyopharm highlight the Company’s competitive compensation and benefits package as a key reason for joining the company. In addition, Karyopharm offers an industry-leading flexible work model, including remote work for most home-office employees with a monthly Core-Weeks to foster in-person collaboration; as well as KaryoFlex Fridays and Flexible Time Off policies that encourages employees to prioritize their work-life balance. To further promote personal wellbeing, Karyopharm provides an annual $1,200 wellness stipend, access to mindfulness resources through Headspace, and two comprehensive medical plans with HRA and HSA options tailored to meet individual and family needs (Karyopharm provides initial funding for employees’ HSA account and employees have the option to also contribute to this tax-advantaged savings account that can be used to pay for medical, dental, vision, and other qualified expenses now or later in life). Additionally, Karyopharm’s tuition assistance program and other talent development offerings reflect the Company’s commitment to the personal and professional growth of its employees.
if you want to do something that matters, this work matters. patients drive our passion to pioneer novel cancer therapies. that’s why we’ve built an environment centered around support, flexibility, and a shared mission. creating and delivering medicine for cancer can only be done through focus, dedication, and heart. we hire exceptional people and trust each other to work in whatever way lets us, be us - whether that’s onsite, from home, or anywhere in between. what do you get when you pair an extraordinary mission with a culture of flexibility and empowerment? we invite you to find out and join us on this incredible mission.
